Development and Evaluation of Mouth Dissolving Tablets of Montelukast Sodium Using Co-processed Excipients

Background: The concept of formulating ODT containing montelukast sodium offers an appropriate, practical approach to accomplish fast release the drug. Absorption these tablets takes place directly into systemic circulation which bipass hepatic first-pass metabolism ultimately results in improvement bioavailability.
 Method: In present study were prepared by using different Superdisintegrants like natural and synthetic (tulasi, hibiscus, orange peel powder, Ispaghula, banana Crospovidone). Thirteen formulations designed, a two level (minimum maximum concentration) employing at time co-processed technique.
 Results: No significant drug excipients interaction was observed. evaluated weight variation, thickness, hardness, friability, content uniformity, disintegration time, wetting in-vitro dissolution studies. A formulation 6mg offered relatively rapid when compared with other concentrations employed this investigation.
 Conclusion: Montelukast Crospovidone ispaghula combination releases 98.91% 30 min.